![]() ![]() An accurate evaluation of RNFL and ONH damage thus seems to be crucial for an early diagnosis of glaucoma. There is increasing evidence in the literature that ONH and peripapillary RNFL structural damage may precede SAP VF loss ( Quigley et al. Although standard automated perimetry (SAP) is still considered to be the gold standard for the diagnosis of visual field (VF) defects, several studies have demonstrated that it can only detect VF loss after a significant percentage (30–40%) of nerve fibre loss ( Quigley et al. Glaucoma is a chronic optic neuropathy in which morphological changes occur at the optic nerve head (ONH) and the retinal nerve fibre layer (RNFL), which may be associated with functional deficits (visual field defects). The best performing indices for the GDx VCC and Stratus OCT with both ONH and RNFL scans gave similar AROCs, showing a moderate sensitivity in early-to-moderate glaucoma patients. The nerve fibre indicator provided the greatest AROC for the GDx VCC indices (0.85).Ĭonclusions: Both the GDx VCC and Stratus OCT instruments were shown to be useful in the detection of glaucomatous damage. Results: The largest AROCs with Stratus OCT were associated with cup : disc area ratio (0.88) for ONH scan indices, and with average thickness (0.84) for RNFL scan indices. Sensitivity at ≥ 90% specificity and area under the receiver operating characteristic curve (AROC) were calculated for each GDx VCC and Stratus OCT index. Methods: A total of 95 glaucomatous patients (mean deviation − 3.7 ± 3.0 dB, pattern standard deviation 4.5 ± 2.7 dB) and 62 control subjects underwent imaging by the GDx VCC and Stratus OCT using both optic nerve head (ONH) and retinal nerve fibre layer (RNFL) scan protocols. Purpose: To compare the abilities of scanning laser polarimetry with the variable corneal compensator (GDx VCC) with those of optical coherence tomography (Stratus OCT) in discriminating between healthy and early-to-moderate perimetric glaucomatous eyes. ![]()
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